SSF1/YHR066W Summary Help

Standard Name SSF1 1
Systematic Name YHR066W
Feature Type ORF, Verified
Description Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Suppressor of ste4 (Four) 1
Chromosomal Location
ChrVIII:229335 to 230696 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SSF1 GO evidence and references
  View Computational GO annotations for SSF1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
299 total interaction(s) for 196 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 88
  • Affinity Capture-Western: 38
  • PCA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 98
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 55
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 453
Molecular Weight (Da) 51,764
Isoelectric Point (pI) 10.05
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:229335 to 230696 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1362 229335..230696 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001108
References cited on this page View Complete Literature Guide for SSF1
1) Yu Y and Hirsch JP  (1995) An essential gene pair in Saccharomyces cerevisiae with a potential role in mating. DNA Cell Biol 14(5):411-8
2) Fatica A, et al.  (2002) Ssf1p prevents premature processing of an early pre-60S ribosomal particle. Mol Cell 9(2):341-51
3) Bogengruber E, et al.  (2003) Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. FEMS Yeast Res 3(1):35-43
4) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61