GIC1/YHR061C Summary

GIC1 BASIC INFORMATION

Standard Name	GIC1 1
Systematic Name	YHR061C
Feature Type	ORF, Verified
Description	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain (1, 2)
Name Description	GTPase Interactive Component 1

GO Annotations	All GIC1 GO evidence and references
	View Computational GO annotations for GIC1
Molecular Function
Manually curated	Rho GTPase activator activity (IDA, IGI, IPI) Rho GTPase binding (IPI)
Biological Process
Manually curated	axial cellular bud site selection (TAS) establishment of cell polarity (IGI) regulation of exit from mitosis (IMP, IPI) Rho protein signal transduction (TAS)
Cellular Component
Manually curated	actin cap (TAS) cellular bud neck (IDA) cellular bud tip (IDA) incipient cellular bud site (IDA) mating projection tip (IDA)

Mutant Phenotype	All GIC1 Phenotype details and references
Classical genetics
overexpression	cell size: increased cellular morphology: abnormal
Large-scale survey
null	viable
overexpression	silencing: abnormal vegetative growth: decreased

Interactions	GIC1 All interactions details and references
	84 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 2 Reconstituted Complex: 6 Two-hybrid: 28
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 22 Phenotypic Enhancement: 7 Phenotypic Suppression: 3 Synthetic Growth Defect: 3 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4 Synthetic Rescue: 2

Sequence Information

ChrVIII:222480 to 221536 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..945	222480..221536	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001103

GIC1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for GIC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GIC1]

1)	Brown JL, et al. (1997) Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev 11(22):2972-82
2)	Kawasaki R, et al. (2003) The upstream regulator, Rsr1p, and downstream effectors, Gic1p and Gic2p, of the Cdc42p small GTPase coordinately regulate initiation of budding in Saccharomyces cerevisiae. Genes Cells 8(3):235-50

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