CIC1/YHR052W Summary

CIC1 BASIC INFORMATION

Standard Name	CIC1 1
Systematic Name	YHR052W
Alias	NSA3
Feature Type	ORF, Verified
Description	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles (1, 2, 3)
Name Description	Core Interacting Component 2

GO Annotations	All CIC1 GO evidence and references
	View Computational GO annotations for CIC1
Molecular Function
Manually curated	protein binding, bridging (IMP, IPI)
Biological Process
Manually curated	protein catabolic process (IDA, IMP, IPI) ribosomal large subunit biogenesis (IPI)
Cellular Component
Manually curated	nucleolus (IDA) preribosome, large subunit precursor (IDA) proteasome complex (IDA, IPI)
High-throughput	preribosome, large subunit precursor (IDA)

Interactions	CIC1 All interactions details and references
	259 total interaction(s) for 123 unique genes/features.
Physical Interactions	Affinity Capture-MS: 237 Affinity Capture-Western: 9 Co-fractionation: 3 Co-purification: 2 PCA: 6
Genetic Interactions	Dosage Rescue: 2

Sequence Information

ChrVIII:210842 to 211972 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1131	210842..211972	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001094

CIC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CIC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CIC1]

1)	Harnpicharnchai P, et al. (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15
2)	Jager S, et al. (2001) Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4. EMBO J 20(16):4423-31
3)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27

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