RRM3/YHR031C Summary Help

Standard Name RRM3 1
Systematic Name YHR031C
Alias RTT104
Feature Type ORF, Verified
Description DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p (2, 3, 4)
Name Description rDNA Recombination Mutation
Chromosomal Location
ChrVIII:172970 to 170799 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RRM3 GO evidence and references
  View Computational GO annotations for RRM3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
322 total interaction(s) for 151 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 141
  • Phenotypic Enhancement: 21
  • Phenotypic Suppression: 17
  • Positive Genetic: 25
  • Synthetic Growth Defect: 48
  • Synthetic Lethality: 58
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 723
Molecular Weight (Da) 81,580
Isoelectric Point (pI) 10.49
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:172970 to 170799 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2172 172970..170799 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001073
References cited on this page View Complete Literature Guide for RRM3
1) Scholes DT, et al.  (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65
2) Ivessa AS, et al.  (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100(4):479-89
3) Makovets S, et al.  (2004) Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol 24(9):4019-31
4) Paeschke K, et al.  (2013) Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature 497(7450):458-62