RPN1/YHR027C Summary Help

Standard Name RPN1 1
Systematic Name YHR027C
Alias HRD2 , NAS1
Feature Type ORF, Verified
Description Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle (2, 3)
Name Description Regulatory Particle Non-ATPase 1
Chromosomal Location
ChrVIII:164711 to 161730 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RPN1 GO evidence and references
  View Computational GO annotations for RPN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
unspecified
Large-scale survey
conditional
overexpression
Resources
678 total interaction(s) for 413 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 509
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 64
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-purification: 43
  • PCA: 4
  • Reconstituted Complex: 27
  • Two-hybrid: 14

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 993
Molecular Weight (Da) 109,491
Isoelectric Point (pI) 4.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:164711 to 161730 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2982 164711..161730 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001069
References cited on this page View Complete Literature Guide for RPN1
1) Finley D, et al.  (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2) Glickman MH, et al.  (1998) A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94(5):615-23
3) Elsasser S, et al.  (2002) Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol 4(9):725-30