RPN1/YHR027C Summary

RPN1 BASIC INFORMATION

Standard Name	RPN1 1
Systematic Name	YHR027C
Alias	HRD2 , NAS1
Feature Type	ORF, Verified
Description	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions (2, 3)
Name Description	Regulatory Particle Non-ATPase 1

GO Annotations	All RPN1 GO evidence and references
	View Computational GO annotations for RPN1
Molecular Function
Manually curated	contributes_to endopeptidase activity (TAS) protein binding, bridging (IPI)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, base subcomplex (IPI) proteasome storage granule (IDA)
High-throughput	cytoplasm (IDA) endoplasmic reticulum (IDA)

Mutant Phenotype	All RPN1 Phenotype details and references
Classical genetics
unspecified	resistance to lovastatin: increased resistance to canavanine: decreased

Interactions	RPN1 All interactions details and references
	538 total interaction(s) for 386 unique genes/features.
Physical Interactions	Affinity Capture-MS: 456 Affinity Capture-RNA: 1 Affinity Capture-Western: 33 Co-fractionation: 1 Co-purification: 26 PCA: 3 Reconstituted Complex: 7 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrVIII:164704 to 161723 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2982	164704..161723	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001069

RPN1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RPN1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPN1]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Glickman MH, et al. (1998) A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94(5):615-23
3)	Elsasser S, et al. (2002) Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol 4(9):725-30

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