THR1/YHR025W Summary Help

Standard Name THR1 1
Systematic Name YHR025W
Feature Type ORF, Verified
Description Homoserine kinase; conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway (2, 3)
Name Description THReonine requiring
Chromosomal Location
ChrVIII:159438 to 160511 | ORF Map | GBrowse
Gbrowse
Genetic position: 26 cM
Gene Ontology Annotations All THR1 GO evidence and references
  View Computational GO annotations for THR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 10 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
112 total interaction(s) for 101 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • Co-purification: 1
  • PCA: 2
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 34
  • Positive Genetic: 20
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 12
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 357
Molecular Weight (Da) 38,712
Isoelectric Point (pI) 5.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:159438 to 160511 | ORF Map | GBrowse
SGD ORF map
Genetic position: 26 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1074 159438..160511 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001067
References cited on this page View Complete Literature Guide for THR1
1) Mortimer RK and Hawthorne DC  (1966) Genetic mapping in Saccharomyces. Genetics 53(1):165-73
2) Mannhaupt G, et al.  (1990) Yeast homoserine kinase. Characteristics of the corresponding gene, THR1, and the purified enzyme, and evolutionary relationships with other enzymes of threonine metabolism. Eur J Biochem 191(1):115-22
3) Schultes NP, et al.  (1990) Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Gene 96(2):177-80