NEM1/YHR004C Summary Help

Standard Name NEM1 1
Systematic Name YHR004C
Feature Type ORF, Verified
Description Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard (1, 2, 3)
Name Description Nuclear Envelope Morphology 1
Chromosomal Location
ChrVIII:113094 to 111754 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NEM1 GO evidence and references
  View Computational GO annotations for NEM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
172 total interaction(s) for 101 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 76
  • Phenotypic Enhancement: 27
  • Phenotypic Suppression: 26
  • Positive Genetic: 18
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 446
Molecular Weight (Da) 50,641
Isoelectric Point (pI) 9.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:113094 to 111754 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1341 113094..111754 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001046
References cited on this page View Complete Literature Guide for NEM1
1) Siniossoglou S, et al.  (1998) A novel complex of membrane proteins required for formation of a spherical nucleus. EMBO J 17(22):6449-64
2) Santos-Rosa H, et al.  (2005) The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. EMBO J 24(11):1931-41
3) Kim Y, et al.  (2007) A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci U S A 104(16):6596-601