CBP2/YHL038C Summary Help

Standard Name CBP2 1
Systematic Name YHL038C
Feature Type ORF, Verified
Description Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene (2, 3, 4, 5)
Name Description Cytochrome B mRNA Processing 1
Chromosomal Location
ChrVIII:25509 to 23617 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All CBP2 GO evidence and references
  View Computational GO annotations for CBP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
19 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 3
  • Positive Genetic: 10
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 630
Molecular Weight (Da) 73,860
Isoelectric Point (pI) 9.7
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:25509 to 23617 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1893 25509..23617 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001030
References cited on this page View Complete Literature Guide for CBP2
1) McGraw P and Tzagoloff A  (1983) Assembly of the mitochondrial membrane system. Characterization of a yeast nuclear gene involved in the processing of the cytochrome b pre-mRNA. J Biol Chem 258(15):9459-68
2) Tirupati HK, et al.  (1999) An RNA binding motif in the Cbp2 protein required for protein-stimulated RNA catalysis. J Biol Chem 274(43):30393-401
3) Gampel A, et al.  (1989) CBP2 protein promotes in vitro excision of a yeast mitochondrial group I intron. Mol Cell Biol 9(12):5424-33
4) Gampel A and Cech TR  (1991) Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA. Genes Dev 5(10):1870-80
5) Shaw LC and Lewin AS  (1997) The Cbp2 protein stimulates the splicing of the omega intron of yeast mitochondria. Nucleic Acids Res 25(8):1597-604