SBP1/YHL034C Summary Help

Standard Name SBP1
Systematic Name YHL034C
Alias SSBR1 , SSB1 1
Feature Type ORF, Verified
Description Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Chromosomal Location
ChrVIII:34077 to 33193 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SBP1 GO evidence and references
  View Computational GO annotations for SBP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Classical genetics
Large-scale survey
1226 total interaction(s) for 1115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 109
  • Affinity Capture-RNA: 1037
  • Affinity Capture-Western: 2
  • Biochemical Activity: 3
  • Co-fractionation: 2
  • PCA: 2
  • Protein-RNA: 3
  • Reconstituted Complex: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 39
  • Positive Genetic: 13
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2

Expression Summary
Length (a.a.) 294
Molecular Weight (Da) 32,989
Isoelectric Point (pI) 5.45
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:34077 to 33193 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..885 34077..33193 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001026
References cited on this page View Complete Literature Guide for SBP1
1) Jong AY and Campbell JL  (1986) Isolation of the gene encoding yeast single-stranded nucleic acid binding protein 1. Proc Natl Acad Sci U S A 83(4):877-81
2) Clark MW, et al.  (1990) SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs. J Cell Biol 111(5 Pt 1):1741-51
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Segal SP, et al.  (2006) Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae. Mol Cell Biol 26(13):5120-30
5) Rajyaguru P, et al.  (2012) Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins. Mol Cell 45(2):244-54
6) Mitchell SF, et al.  (2013) Global analysis of yeast mRNPs. Nat Struct Mol Biol 20(1):127-33