SBP1/YHL034C Summary

SBP1 BASIC INFORMATION

Standard Name	SBP1
Systematic Name	YHL034C
Alias	SSBR1 , SSB1 1
Feature Type	ORF, Verified
Description	Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 (1, 2, 3)

GO Annotations	All SBP1 GO evidence and references
	View Computational GO annotations for SBP1
Molecular Function
Manually curated	RNA binding (NAS)
Biological Process
Manually curated	negative regulation of translation in response to stress (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) cytoplasmic mRNA processing body (IDA) nucleolus (IDA)

Mutant Phenotype	All SBP1 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased viable

Interactions	SBP1 All interactions details and references
	124 total interaction(s) for 96 unique genes/features.
Physical Interactions	Affinity Capture-MS: 95 Biochemical Activity: 3 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 11 Phenotypic Suppression: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 1

Sequence Information

ChrVIII:34075 to 33191 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..885	34075..33191	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001026

SBP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SBP1

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
SSB1	Nomenclature conflict	SSB1 has been used to refer to both SBP1/YHL034C, which encodes a putative RNA-binding protein involved in repressing translation of mRNAs, and SSB1/YDL229W, which encodes a chaperone of the HSP70 family.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SBP1]

1)	Jong AY and Campbell JL (1986) Isolation of the gene encoding yeast single-stranded nucleic acid binding protein 1. Proc Natl Acad Sci U S A 83(4):877-81
2)	Clark MW, et al. (1990) SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs. J Cell Biol 111(5 Pt 1):1741-51
3)	Segal SP, et al. (2006) Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae. Mol Cell Biol 26(13):5120-30

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