SBP1/YHL034C Summary Help

Standard Name SBP1
Systematic Name YHL034C
Alias SSBR1 , SSB1 1
Feature Type ORF, Verified
Description Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Chromosomal Location
ChrVIII:34077 to 33193 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SBP1 GO evidence and references
  View Computational GO annotations for SBP1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
1226 total interaction(s) for 1115 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 109
  • Affinity Capture-RNA: 1037
  • Affinity Capture-Western: 2
  • Biochemical Activity: 3
  • Co-fractionation: 2
  • PCA: 2
  • Protein-RNA: 3
  • Reconstituted Complex: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 39
  • Positive Genetic: 13
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 294
Molecular Weight (Da) 32,989
Isoelectric Point (pI) 5.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:34077 to 33193 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..885 34077..33193 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001026
References cited on this page View Complete Literature Guide for SBP1
1) Jong AY and Campbell JL  (1986) Isolation of the gene encoding yeast single-stranded nucleic acid binding protein 1. Proc Natl Acad Sci U S A 83(4):877-81
2) Clark MW, et al.  (1990) SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs. J Cell Biol 111(5 Pt 1):1741-51
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Segal SP, et al.  (2006) Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae. Mol Cell Biol 26(13):5120-30
5) Rajyaguru P, et al.  (2012) Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins. Mol Cell 45(2):244-54
6) Mitchell SF, et al.  (2013) Global analysis of yeast mRNPs. Nat Struct Mol Biol 20(1):127-33