GOS1/YHL031C Summary

GOS1 BASIC INFORMATION

Standard Name	GOS1
Systematic Name	YHL031C
Feature Type	ORF, Verified
Description	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 (1)
Name Description	GOlgi Snare 2

GO Annotations	All GOS1 GO evidence and references
	View Computational GO annotations for GOS1
Molecular Function
Manually curated	SNAP receptor activity (TAS)
Biological Process
Manually curated	intra-Golgi vesicle-mediated transport (TAS) vesicle fusion (TAS)
High-throughput	response to drug (IMP)
Cellular Component
Manually curated	integral to membrane (ISS, NAS)

Mutant Phenotype	All GOS1 Phenotype details and references
Classical genetics
overexpression	resistance to hydroxyurea: decreased
Large-scale survey
null	UV resistance: decreased acid pH resistance: decreased polyphosphate accumulation: abnormal competitive fitness: decreased metal resistance: decreased Can1p-GFP distribution: abnormal resistance to rapamycin: decreased resistance to wortmannin: normal resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to nickel sulfate: increased viable
overexpression	cell cycle progression in G1 phase: abnormal vegetative growth: decreased

Interactions	GOS1 All interactions details and references
	159 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-Western: 7 Co-fractionation: 1 Co-localization: 1 Co-purification: 2 Reconstituted Complex: 14 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Phenotypic Enhancement: 104 Phenotypic Suppression: 2 Synthetic Growth Defect: 6 Synthetic Lethality: 15 Synthetic Rescue: 2

Sequence Information

ChrVIII:39484 to 38813 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..672	39484..38813	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001023

GOS1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for GOS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GOS1]

1)	McNew JA, et al. (1998) Gos1p, a Saccharomyces cerevisiae SNARE protein involved in Golgi transport. FEBS Lett 435(1):89-95
2)	McNew JA, et al. (1997) Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem 272(28):17776-83

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.