WSC4/YHL028W Summary Help

WSC4 BASIC INFORMATION

Standard Name WSC4 1
Systematic Name YHL028W
Alias YHC8 2 , YFW1 3
Feature Type ORF, Verified
Description ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 (4, 5)
Name Description cell Wall integrity and Stress response Component 1
GO Annotations All WSC4 GO evidence and references
    View Computational GO annotations for WSC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle ( 293 , 251 )
Mutant Phenotype All WSC4 Phenotype details and references
Large-scale survey
null
Interactions WSC4 All interactions details and references
4 total interaction(s) for 4 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
Genetic Interactions
  • Dosage Rescue: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1
Sequence Information
ChrVIII:48761 to 50578 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1818 48761..50578 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001020

WSC4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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Expression Summary histogram

ADDITIONAL INFORMATION for WSC4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for WSC4]

1) Verna J, et al.  (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9
2) Mamoun CB, et al.  (1996) The TSR1 gene of Yarrowia lipolytica is involved in the signal recognition particle-dependent translocation pathway of secretory proteins. J Biol Chem 271(39):23895-901
3) Wei YF, et al.  (1995) Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes. J Bacteriol 177(17):5009-15
4) Mamoun CB, et al.  (1999) Disruption of YHC8, a member of the TSR1 gene family, reveals its direct involvement in yeast protein translocation. J Biol Chem 274(16):11296-302
5) Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55