Standard Name	DUR3 1
Systematic Name	YHL016C
Feature Type	ORF, Verified
Description	Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway (2, 3, 4, 5)
Name Description	Degradation of URea 3

Chromosomal Location	ChrVIII:74244 to 72037 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -13 cM

	View Computational GO annotations for DUR3
Molecular Function
Manually curated	putrescine transmembrane transporter activity (IDA, IMP) spermidine transmembrane transporter activity (IDA, IMP) urea transmembrane transporter activity (IMP, ISS)
Biological Process
Manually curated	putrescine transport (IDA, IMP) spermidine transport (IDA, IMP) urea catabolic process (IEP) urea transport (IMP, ISS)
Cellular Component
Manually curated	plasma membrane (IDA, IMP, ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	nutrient uptake: decreased resistance to sirolimus: increased
overexpression	nutrient uptake: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to cycloheximide: decreased resistance to amitrole: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	25 total interaction(s) for 24 unique genes/features.
Physical Interactions	PCA: 13 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 10 Positive Genetic: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:74244 to 72037 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -13 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2208 74244..72037 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000001008