PRS3/YHL011C Summary Help

Standard Name PRS3 1
Systematic Name YHL011C
Feature Type ORF, Verified
Description 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes (1, 2, 3)
Name Description PhosphoRibosylpyrophosphate Synthetase 4
Chromosomal Location
ChrVIII:81616 to 80654 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PRS3 GO evidence and references
  View Computational GO annotations for PRS3
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
High-throughput
Regulators 3 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
overexpression
Resources
59 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 3
  • PCA: 2
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 5
  • Phenotypic Enhancement: 1
  • Positive Genetic: 1
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 7
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 320
Molecular Weight (Da) 35,123
Isoelectric Point (pI) 8.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:81616 to 80654 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..963 81616..80654 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001003
References cited on this page View Complete Literature Guide for PRS3
1) Carter AT, et al.  (1997) PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Mol Gen Genet 254(2):148-56
2) Hernando Y, et al.  (1999) Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem 274(18):12480-7
3) Hernando Y, et al.  (1998) PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. J Bacteriol 180(23):6404-7
4) Carter AT, et al.  (1994) Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae. Yeast 10(8):1031-44