SHU1/YHL006C Summary Help

Standard Name SHU1 1
Systematic Name YHL006C
Feature Type ORF, Verified
Description Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function (1, 2, 3, 4, 5)
Name Description Suppressor of HU sensitivity 1
Chromosomal Location
ChrVIII:98795 to 98343 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SHU1 GO evidence and references
  View Computational GO annotations for SHU1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 88 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
48 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Co-purification: 1
  • PCA: 1
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 8
  • Phenotypic Suppression: 4
  • Positive Genetic: 5
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 150
Molecular Weight (Da) 17,121
Isoelectric Point (pI) 8.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:98795 to 98343 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-01-29
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..453 98795..98343 2011-02-03 2004-01-29
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000998
References cited on this page View Complete Literature Guide for SHU1
1) Shor E, et al.  (2005) A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Genetics 169(3):1275-89
2) Huang ME, et al.  (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34
3) Mankouri HW, et al.  (2007) Shu proteins promote the formation of homologous recombination intermediates that are processed by sgs1-rmi1-top3. Mol Biol Cell 18(10):4062-73
4) Ball LG, et al.  (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102
5) Bernstein KA, et al.  (2011) The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Mol Biol Cell 22(9):1599-607