HSE1/YHL002W Summary Help

Standard Name HSE1 1
Systematic Name YHL002W
Feature Type ORF, Verified
Description Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes (1, 2)
Name Description Has Symptoms of class E mutants; resembles Hbp, Stam and East 1
Chromosomal Location
ChrVIII:102612 to 103970 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HSE1 GO evidence and references
  View Computational GO annotations for HSE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
137 total interaction(s) for 96 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-Western: 12
  • Co-crystal Structure: 2
  • PCA: 3
  • Reconstituted Complex: 7
  • Two-hybrid: 52

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 32
  • Positive Genetic: 4
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 452
Molecular Weight (Da) 51,160
Isoelectric Point (pI) 6.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:102612 to 103970 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1359 102612..103970 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000994
References cited on this page View Complete Literature Guide for HSE1
1) Bilodeau PS, et al.  (2002) The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nat Cell Biol 4(7):534-9
2) Bilodeau PS, et al.  (2003) Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome. J Cell Biol 163(2):237-43