Standard Name	HSE1 1
Systematic Name	YHL002W
Feature Type	ORF, Verified
Description	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes (1, 2)
Name Description	Has Symptoms of class E mutants; resembles Hbp, Stam and East 1

Chromosomal Location	ChrVIII:102612 to 103970 | ORF Map | GBrowse

	View Computational GO annotations for HSE1
Molecular Function
Manually curated	ubiquitin binding (IDA)
Biological Process
Manually curated	late endosome to vacuole transport (IMP) protein targeting to vacuole (IMP, IPI)
Cellular Component
Manually curated	endosome (IDA) ESCRT-0 complex (IPI)

Classical genetics
null	oxidative stress resistance: increased resistance to caffeine: decreased resistance to tunicamycin: decreased
overexpression	budding: abnormal cellular morphology: abnormal resistance to caffeine: increased
Large-scale survey
null	chitin deposition: decreased competitive fitness: decreased endocytosis: decreased haploproficient replicative lifespan: increased resistance to (S)-lactic acid: increased resistance to fenpropimorph: increased resistance to Calcofluor White: decreased resistance to bleomycin: decreased resistance to tunicamycin: decreased stress resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	133 total interaction(s) for 97 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 12 Co-crystal Structure: 1 PCA: 3 Reconstituted Complex: 5 Two-hybrid: 52
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 32 Positive Genetic: 4 Synthetic Growth Defect: 6 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:102612 to 103970 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1359 102612..103970 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000994