Standard Name	GRX4 1
Systematic Name	YER174C
Feature Type	ORF, Verified
Description	Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog, GRX3, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	GlutaRedoXin 1

Chromosomal Location	ChrV:539168 to 538434 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GRX4
Molecular Function
Manually curated	disulfide oxidoreductase activity (IGI, IMP, ISS)
Biological Process
Manually curated	actin cytoskeleton organization (IMP) cellular iron ion homeostasis (IGI, IPI) cellular response to oxidative stress (IGI, IMP)
Cellular Component
Manually curated	nucleus (IGI, IPI)

Pathways	glutathione-glutaredoxin system

Classical genetics
null	actin cytoskeleton morphology: abnormal oxidative stress resistance: decreased
overexpression	oxidative stress resistance: increased
Large-scale survey
null	auxotrophy competitive fitness: increased metal resistance: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased stress resistance: increased toxin resistance: increased viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	59 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-Western: 8 Biochemical Activity: 4 Reconstituted Complex: 11 Two-hybrid: 8
Genetic Interactions	Negative Genetic: 11 Phenotypic Suppression: 2 Positive Genetic: 2 Synthetic Growth Defect: 5 Synthetic Haploinsufficiency: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:539168 to 538434 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..735 539168..538434 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000976