RAD24/YER173W Summary

RAD24 BASIC INFORMATION

Standard Name	RAD24 1
Systematic Name	YER173W
Feature Type	ORF, Verified
Description	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein (2, 3, 4) Also known as: RS1
Name Description	RADiation sensitive

GO Annotations	All RAD24 GO evidence and references
	View Computational GO annotations for RAD24
Molecular Function
Manually curated	contributes_to DNA clamp loader activity (IDA)
Biological Process
Manually curated	DNA damage checkpoint (IMP) nucleotide-excision repair (IMP) reciprocal meiotic recombination (IMP)
Cellular Component
Manually curated	nucleus (IPI) Rad17 RFC-like complex (IDA)

Mutant Phenotype	All RAD24 Phenotype details and references
Classical genetics
null	UV resistance: decreased chromosome/plasmid maintenance: abnormal resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to selenite(2-): decreased
Large-scale survey
null	UV resistance: decreased resistance to nickel(2+): decreased resistance to hydroxyurea: decreased resistance to 5-fluorouracil: decreased resistance to methyl methanesulfonate: decreased transposable element transposition: decreased viable

Interactions	RAD24 All interactions details and references
	231 total interaction(s) for 120 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-Western: 14 Biochemical Activity: 1 Co-fractionation: 1 Co-localization: 1 Co-purification: 4 Reconstituted Complex: 7 Two-hybrid: 6
Genetic Interactions	Dosage Lethality: 9 Dosage Rescue: 4 Phenotypic Enhancement: 70 Phenotypic Suppression: 19 Synthetic Growth Defect: 43 Synthetic Lethality: 32 Synthetic Rescue: 10

Sequence Information

ChrV:536295 to 538274 | |

Genetic position: 147 cM

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1980	536295..538274	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000975

RAD24 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RAD24

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RAD24]

1)	Eckardt, F. and Game, J. (1985) Personal Communication, Mortimer Map Edition 9
2)	Lydall D, et al. (1996) A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383(6603):840-3
3)	Majka J and Burgers PM (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A 100(5):2249-54
4)	Shinohara M, et al. (2003) The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast. Genetics 164(3):855-65

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