ADK2/YER170W Summary Help

Standard Name ADK2 1
Systematic Name YER170W
Alias AKY3 2 , PAK3 2
Feature Type ORF, Verified
Description Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background (3)
Name Description ADenylate Kinase 1
Chromosomal Location
ChrV:525974 to 526651 | ORF Map | GBrowse
Gbrowse
Genetic position: 146 cM
Gene Ontology Annotations All ADK2 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Pathways
Large-scale survey
null
Resources
16 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • PCA: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 4
  • Positive Genetic: 6
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 225
Molecular Weight (Da) 25,194
Isoelectric Point (pI) 9.76
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:525974 to 526651 | ORF Map | GBrowse
SGD ORF map
Genetic position: 146 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..678 525974..526651 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000972
References cited on this page View Complete Literature Guide for ADK2
1) Cooper AJ and Friedberg EC  (1992) A putative second adenylate kinase-encoding gene from the yeast Saccharomyces cerevisiae. Gene 114(1):145-8
2) Schricker R, et al.  (1995) Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae. J Biol Chem 270(52):31103-10
3) Gu Y, et al.  (2005) A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity. J Biol Chem 280(19):18604-9