BUR6/YER159C Summary

BUR6 BASIC INFORMATION

Standard Name	BUR6
Systematic Name	YER159C
Alias	NCB1
Feature Type	ORF, Verified
Description	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha (1, 2, 3, 4)
Name Description	Bypass UAS Requirement 5

GO Annotations	All BUR6 GO evidence and references
	View Computational GO annotations for BUR6
Molecular Function
Manually curated	transcription coactivator activity (IDA) transcription corepressor activity (IGI, IMP)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IGI, IMP) positive regulation of transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	nucleus (IPI)

Mutant Phenotype	All BUR6 Phenotype details and references
Classical genetics
unspecified	utilization of carbon source: decreased
Large-scale survey
null	inviable vegetative growth: decreased

Interactions	BUR6 All interactions details and references
	54 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 8 Co-localization: 3 PCA: 2 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 4 Phenotypic Suppression: 1 Synthetic Lethality: 6 Synthetic Rescue: 24

Sequence Information

ChrV:491953 to 491525 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..429	491953..491525	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000961

BUR6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BUR6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BUR6]

1)	Kim S, et al. (1997) The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A 94(3):820-5
2)	Goppelt A and Meisterernst M (1996) Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae. Nucleic Acids Res 24(22):4450-5
3)	Estruch F and Cole CN (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76
4)	Cang Y and Prelich G (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32
5)	Prelich G and Winston F (1993) Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo. Genetics 135(3):665-76

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