PEA2/YER149C Summary Help

Standard Name PEA2 1
Systematic Name YER149C
Alias DFG9 2 , PPF2 3 , 4
Feature Type ORF, Verified
Description Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion (1, 3, 5, 6, 7, 8)
Name Description PEAnut shmoo mutant 1
Chromosomal Location
ChrV:467470 to 466208 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All PEA2 GO evidence and references
Molecular Function
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Classical genetics
reduction of function
Large-scale survey
94 total interaction(s) for 70 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 19

Genetic Interactions
  • Negative Genetic: 36
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 9
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 15
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 420
Molecular Weight (Da) 48,164
Isoelectric Point (pI) 5.37
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrV:467470 to 466208 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1263 467470..466208 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000951
References cited on this page View Complete Literature Guide for PEA2
1) Chenevert J, et al.  (1994) Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae. Genetics 136(4):1287-96
2) Mosch HU and Fink GR  (1997) Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae. Genetics 145(3):671-84
3) Valtz N and Herskowitz I  (1996) Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding. J Cell Biol 135(3):725-39
4) Yorihuzi T and Ohsumi Y  (1994) Saccharomyces cerevisiae MATa mutant cells defective in pointed projection formation in response to alpha-factor at high concentrations. Yeast 10(5):579-94
5) Sheu YJ, et al.  (2000) Polarized growth controls cell shape and bipolar bud site selection in Saccharomyces cerevisiae. Mol Cell Biol 20(14):5235-47
6) Sagot I, et al.  (2002) Yeast formins regulate cell polarity by controlling the assembly of actin cables. Nat Cell Biol 4(1):42-50
7) Li X, et al.  (2013) Different polarisome components play distinct roles in Slt2p-regulated cortical ER inheritance in Saccharomyces cerevisiae. Mol Biol Cell 24(19):3145-54
8) Song Q, et al.  (2014) Pooled segregant sequencing reveals genetic determinants of yeast pseudohyphal growth. PLoS Genet 10(8):e1004570