Standard Name	RTR1 1
Systematic Name	YER139C
Feature Type	ORF, Verified
Description	CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Regulator of TRanscription 1

Chromosomal Location	ChrV:451243 to 450563 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RTR1
Molecular Function
Manually curated	CTD phosphatase activity (IDA)
Biological Process
Manually curated	dephosphorylation of RNA polymerase II C-terminal domain (IDA, IMP) transcription from RNA polymerase II promoter (IGI, IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
conditional	resistance to formamide: decreased resistance to mycophenolic acid: decreased
null	heat sensitivity: increased Rpo21p modification: abnormal
overexpression	growth in exponential phase: decreased rate
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased resistance to fluconazole: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to hygromycin B: decreased resistance to benzo[a]pyrene: decreased resistance to tunicamycin: increased resistance to bleomycin: decreased resistance to dimethyl sulfoxide: decreased resistance to camptothecin: increased sporulation efficiency: increased stress resistance: increased toxin resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	129 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 2 Co-purification: 1 Reconstituted Complex: 10 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 4 Negative Genetic: 28 Positive Genetic: 2 Synthetic Growth Defect: 16 Synthetic Lethality: 6 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:451243 to 450563 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..681 451243..450563 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000941