COM2/YER130C Summary Help

Standard Name COM2 1, 2
Systematic Name YER130C
Feature Type ORF, Verified
Description Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress (1, 3, 4, 5, 6, 7, 8)
Name Description Cousin of Msn2 2
Chromosomal Location
ChrV:422446 to 421115 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All COM2 GO evidence and references
  View Computational GO annotations for COM2
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Resources
Large-scale survey
null
Resources
20 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 9
  • Positive Genetic: 5
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 443
Molecular Weight (Da) 50,319
Isoelectric Point (pI) 5.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:422446 to 421115 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1332 422446..421115 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000932
References cited on this page View Complete Literature Guide for COM2
1) Kahana-Edwin S, et al.  (2013) Multiple MAPK Cascades Regulate the Transcription of IME1, the Master Transcriptional Activator of Meiosis in Saccharomyces cerevisiae. PLoS One 8(11):e78920
2) Jandric Z, et al.  (2013) Sorbic acid stress activates the Candida glabrata high osmolarity glycerol MAP kinase pathway. Front Microbiol 4():350
3) Vachova L, et al.  (2004) Sok2p transcription factor is involved in adaptive program relevant for long term survival of Saccharomyces cerevisiae colonies. J Biol Chem 279(36):37973-81
4) Fernandes AR, et al.  (2005) Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes. Biochem Biophys Res Commun 337(1):95-103
5) De Nicola R, et al.  (2007) Physiological and Transcriptional Responses of Saccharomyces cerevisiae to Zinc Limitation in Chemostat Cultures. Appl Environ Microbiol 73(23):7680-92
6) Ramsdale M, et al.  (2008) MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell 19(10):4393-403
7) Mira NP, et al.  (2010) Genomic Expression Program Involving the Haa1p-Regulon in Saccharomyces cerevisiae Response to Acetic Acid. OMICS 14(5):587-601
8) Yang Y, et al.  (2010) Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Cell Res 20(11):1276-8