COM2/YER130C Summary Help

Standard Name COM2 1, 2
Systematic Name YER130C
Feature Type ORF, Verified
Description Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress (1, 3, 4, 5, 6, 7, 8)
Name Description Cousin of Msn2 2
Chromosomal Location
ChrV:422446 to 421115 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All COM2 GO evidence and references
  View Computational GO annotations for COM2
Molecular Function
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Large-scale survey
20 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 9
  • Positive Genetic: 5
  • Synthetic Lethality: 2

Expression Summary
Length (a.a.) 443
Molecular Weight (Da) 50,319
Isoelectric Point (pI) 5.59
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrV:422446 to 421115 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1332 422446..421115 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000932
References cited on this page View Complete Literature Guide for COM2
1) Kahana-Edwin S, et al.  (2013) Multiple MAPK Cascades Regulate the Transcription of IME1, the Master Transcriptional Activator of Meiosis in Saccharomyces cerevisiae. PLoS One 8(11):e78920
2) Jandric Z, et al.  (2013) Sorbic acid stress activates the Candida glabrata high osmolarity glycerol MAP kinase pathway. Front Microbiol 4():350
3) Vachova L, et al.  (2004) Sok2p transcription factor is involved in adaptive program relevant for long term survival of Saccharomyces cerevisiae colonies. J Biol Chem 279(36):37973-81
4) Fernandes AR, et al.  (2005) Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes. Biochem Biophys Res Commun 337(1):95-103
5) De Nicola R, et al.  (2007) Physiological and Transcriptional Responses of Saccharomyces cerevisiae to Zinc Limitation in Chemostat Cultures. Appl Environ Microbiol 73(23):7680-92
6) Ramsdale M, et al.  (2008) MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell 19(10):4393-403
7) Mira NP, et al.  (2010) Genomic Expression Program Involving the Haa1p-Regulon in Saccharomyces cerevisiae Response to Acetic Acid. OMICS 14(5):587-601
8) Yang Y, et al.  (2010) Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Cell Res 20(11):1276-8