LCP5/YER127W Summary Help

Standard Name LCP5 1
Systematic Name YER127W
Feature Type ORF, Verified
Description Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus (1)
Name Description Lethal with Conditional Pap1 1
Chromosomal Location
ChrV:414481 to 415554 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LCP5 GO evidence and references
  View Computational GO annotations for LCP5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Large-scale survey
null
overexpression
repressible
Resources
84 total interaction(s) for 80 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 14
  • Positive Genetic: 37
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 357
Molecular Weight (Da) 40,794
Isoelectric Point (pI) 6.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:414481 to 415554 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1074 414481..415554 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000929
References cited on this page View Complete Literature Guide for LCP5
1) Wiederkehr T, et al.  (1998) Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation. RNA 4(11):1357-72