DSE1/YER124C Summary Help

Standard Name DSE1 1
Systematic Name YER124C
Feature Type ORF, Verified
Description Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress (1, 2, 3, 4)
Name Description Daughter Specific Expression 1
Chromosomal Location
ChrV:409063 to 407342 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All DSE1 GO evidence and references
  View Computational GO annotations for DSE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
45 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Two-hybrid: 11

Genetic Interactions
  • Negative Genetic: 22
  • Phenotypic Suppression: 1
  • Positive Genetic: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 573
Molecular Weight (Da) 63,998
Isoelectric Point (pI) 6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:409063 to 407342 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1722 409063..407342 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000926
References cited on this page View Complete Literature Guide for DSE1
1) Colman-Lerner A, et al.  (2001) Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell 107(6):739-50
2) Doolin MT, et al.  (2001) Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p. Mol Microbiol 40(2):422-32
3) Draper E, et al.  (2009) Dse1 may control cross talk between the pheromone and filamentation pathways in yeast. Curr Genet 55(6):611-21
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76