SUMMARY PARAGRAPH for GLO3
GLO3 encodes a GTPase activating protein (GAP) for ADP ribosylation factors (ARFs, encoded by ARF1, ARF2, and ARF3 in yeast), and interacts genetically with ARF1 and ARF2 (3). ARFs are GTPases of the Ras superfamily that regulate the formation of coated vesicles in intracellular trafficking (4, 5). The process of vesicle formation in the exocytic and endocytic pathways has been recently reviewed (6), as has the role of ARF (7). GCS1 encodes an ARF GAP with sequence similarity to Glo3p; a gcs1 glo3 double deletion is inviable (3). Genetic interactions with BET1, BOS1, and SEC22, which encode v-SNARES, implicate Gcs1p and Glo3p in transport between the ER and the Golgi (3).
Last updated: 1999-10-29