SHO1/YER118C Summary

SHO1 BASIC INFORMATION

Standard Name	SHO1
Systematic Name	YER118C
Alias	SSU81
Feature Type	ORF, Verified
Description	Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway (1, 2, 3)

GO Annotations	All SHO1 GO evidence and references
	View Computational GO annotations for SHO1
Molecular Function
Manually curated	osmosensor activity (TAS)
Biological Process
Manually curated	osmosensory signaling pathway via Sho1 osmosensor (TAS) pseudohyphal growth (IMP)
Cellular Component
Manually curated	mating projection tip (IDA) plasma membrane (ISS)

Regulatory Role
Regulatory modules	predicted: stressResponse ( 487 , 481 , 463 ) predicted: cellcycle ( 359 , 215 ) predicted: stressResponse ( 487 , 481 , 463 ) predicted: cellcycle ( 359 , 215 )

Mutant Phenotype	All SHO1 Phenotype details and references
Classical genetics
null	invasive growth: decreased pseudohyphal growth: decreased resistance to Calcofluor White: increased resistance to enzymatic treatment: decreased
Large-scale survey
null	resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased viable
overexpression	resistance to rapamycin: decreased

Interactions	SHO1 All interactions details and references
	111 total interaction(s) for 78 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 9 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 6 Two-hybrid: 69
Genetic Interactions	Phenotypic Enhancement: 13 Phenotypic Suppression: 3 Synthetic Growth Defect: 3 Synthetic Lethality: 3 Synthetic Rescue: 2

Sequence Information

ChrV:399051 to 397948 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1104	399051..397948	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000920

SHO1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SHO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SHO1]

1)	Posas F and Saito H (1997) Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276(5319):1702-5
2)	O'Rourke SM and Herskowitz I (2004) Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis. Mol Biol Cell 15(2):532-42
3)	Cullen PJ, et al. (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18(14):1695-708

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