Standard Name	SLX8 1
Systematic Name	YER116C
Feature Type	ORF, Verified
Description	Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	Synthetic Lethal of unknown (X) function 1

Chromosomal Location	ChrV:396172 to 395348 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SLX8
Molecular Function
Manually curated	contributes_to ubiquitin-protein ligase activity (IDA) ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	protein sumoylation (IGI, IMP) protein ubiquitination (IDA) response to DNA damage stimulus (IGI, IMP) telomere maintenance (IMP)
Cellular Component
Manually curated	nucleus (IDA) ubiquitin ligase complex (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	UV resistance: decreased chromosome/plasmid maintenance: abnormal colony sectoring: increased Matalpha1p accumulation: increased Sumoylated-Mot1p accumulation: increased resistance to hydroxyurea: decreased resistance to canavanine: decreased
reduction of function	resistance to hydroxyurea: decreased
Large-scale survey
null	UV resistance: decreased auxotrophy cell size: increased glycogen accumulation: decreased glutathione excretion: increased competitive fitness: decreased haploinsufficient heat sensitivity: increased mitotic recombination: increased Rad52-YFP distribution: increased resistance to hydroxyurea: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to methyl methanesulfonate: decreased resistance to sodium selenide: decreased resistance to sodium arsenite: decreased resistance to hygromycin B: decreased resistance to doxorubicin: decreased resistance to 1,4-dithiothreitol: decreased resistance to acrolein: decreased resistance to glycolaldehyde: decreased resistance to benzo[a]pyrene: decreased sporulation: absent stress resistance: increased telomere length: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	468 total interaction(s) for 315 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-Western: 4 Biochemical Activity: 7 Co-purification: 1 Reconstituted Complex: 3 Two-hybrid: 9
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 226 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 61 Synthetic Growth Defect: 92 Synthetic Lethality: 41 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:396172 to 395348 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..825 396172..395348 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000918