SWI4/YER111C Summary 
| Standard Name | SWI4 1 |
|---|---|
| Systematic Name | YER111C |
| Alias | ART1 |
| Feature Type | ORF, Verified |
| Description | DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p (2, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | SWItching deficient 1 |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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Gene Ontology Annotations All SWI4 GO evidence and references
| View Computational GO annotations for SWI4 | |
| Molecular Function | |
| Manually curated | |
| High-throughput | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Regulatory Role
| Binding motifs | Predicted SWI4 Binding Site Locations |
|---|---|
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| Regulatory modules | predicted: cellcycle (257) |
| Resources |
Mutant phenotypes All SWI4 Phenotype evidence and references
interactions All SWI4 Interaction evidence and references
| 795 total interaction(s) for 419 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All SWI4 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000000913 |
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References cited on this page View Complete Literature Guide for SWI4
| 1) | Stern M, et al. (1984) Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 178(4):853-68 |
| 2) | Andrews BJ and Moore LA (1992) Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro. Proc Natl Acad Sci U S A 89(24):11852-6 |
| 3) | Andrews BJ and Herskowitz I (1989) The yeast SWI4 protein contains a motif present in developmental regulators and is part of a complex involved in cell-cycle-dependent transcription. Nature 342(6251):830-3 |
| 4) | Ogas J, et al. (1991) Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Cell 66(5):1015-26 |
| 5) | Nasmyth K and Dirick L (1991) The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell 66(5):995-1013 |
| 6) | Sidorova J and Breeden L (1993) Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(2):1069-77 |
| 7) | Spellman PT, et al. (1998) Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell 9(12):3273-97 |
| 8) | Harrington LA and Andrews BJ (1996) Binding to the yeast SwI4,6-dependent cell cycle box, CACGAAA, is cell cycle regulated in vivo. Nucleic Acids Res 24(4):558-65 |
| 9) | Kaluarachchi Duffy S, et al. (2012) Exploring the yeast acetylome using functional genomics. Cell 149(4):936-48 |
| 10) | Taba MR, et al. (1991) Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast. Genes Dev 5(11):2000-13 |
| 11) | Harbison CT, et al. (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104 |
| 12) | Badis G, et al. (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87 |
