SWI4/YER111C Summary Help

SWI4 BASIC INFORMATION

Standard Name SWI4
Systematic Name YER111C
Alias ART1
Feature Type ORF, Verified
Description DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair (1, 2, 3, 4, 5, 6, 7)
Name Description SWItching deficient 2, 8
GO Annotations All SWI4 GO evidence and references
    View Computational GO annotations for SWI4
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs SWI4 Transcription Factor Binding Sites and References
  • CACGAAAA
  • CGCSAAA
Regulatory modules predicted: cellcycle ( 257 )
Mutant Phenotype All SWI4 Phenotype details and references
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
Interactions SWI4 All interactions details and references
402 total interaction(s) for 255 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 13
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 8
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 23
  • Phenotypic Enhancement: 195
  • Phenotypic Suppression: 37
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 79
  • Synthetic Rescue: 8
Sequence Information
ChrV:385872 to 382591 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3282 385872..382591 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000913

SWI4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SWI4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SWI4]

1) Andrews BJ and Moore LA  (1992) Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro. Proc Natl Acad Sci U S A 89(24):11852-6
2) Andrews BJ and Herskowitz I  (1989) The yeast SWI4 protein contains a motif present in developmental regulators and is part of a complex involved in cell-cycle-dependent transcription. Nature 342(6251):830-3
3) Ogas J, et al.  (1991) Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Cell 66(5):1015-26
4) Nasmyth K and Dirick L  (1991) The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell 66(5):995-1013
5) Sidorova J and Breeden L  (1993) Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(2):1069-77
6) Spellman PT, et al.  (1998) Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell 9(12):3273-97
7) Harrington LA and Andrews BJ  (1996) Binding to the yeast SwI4,6-dependent cell cycle box, CACGAAA, is cell cycle regulated in vivo. Nucleic Acids Res 24(4):558-65
8) Stern M, et al.  (1984) Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 178(4):853-68