KAP123/YER110C Summary

KAP123 BASIC INFORMATION

Standard Name	KAP123
Systematic Name	YER110C
Alias	YRB4
Feature Type	ORF, Verified
Description	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 (1, 2, 3)
Name Description	KAryoPherin

GO Annotations	All KAP123 GO evidence and references
	View Computational GO annotations for KAP123
Molecular Function
Manually curated	protein transporter activity (IMP, IPI)
Biological Process
Manually curated	protein import into nucleus (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pore (IDA) nucleus (IDA)

Mutant Phenotype	All KAP123 Phenotype details and references
Classical genetics
null	nuclear import: normal nuclear import: decreased
Large-scale survey
null	bud morphology: abnormal competitive fitness: decreased filamentous growth: decreased invasive growth: absent resistance to benomyl: decreased resistance to cycloheximide: decreased resistance to ethanol: decreased respiratory growth: decreased rate viable

Interactions	KAP123 All interactions details and references
	190 total interaction(s) for 134 unique genes/features.
Physical Interactions	Affinity Capture-MS: 93 Affinity Capture-Western: 15 Co-purification: 2 Protein-peptide: 2 Reconstituted Complex: 18 Two-hybrid: 6
Genetic Interactions	Phenotypic Enhancement: 35 Phenotypic Suppression: 12 Synthetic Growth Defect: 4 Synthetic Lethality: 2 Synthetic Rescue: 1

Sequence Information

ChrV:382099 to 378758 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3342	382099..378758	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000912

KAP123 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KAP123

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KAP123]

1)	Schlenstedt G, et al. (1997) Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J 16(20):6237-49
2)	Sydorskyy Y, et al. (2003) Intersection of the Kap123p-mediated nuclear import and ribosome export pathways. Mol Cell Biol 23(6):2042-54
3)	Mosammaparast N, et al. (2002) Pathways mediating the nuclear import of histones H3 and H4 in yeast. J Biol Chem 277(1):862-8

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