Standard Name	FLO8 1, 2
Systematic Name	YER109C
Alias	PHD5 3 , YER108C , STA10 4
Feature Type	ORF, Verified
Description	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a nonsense mutation in this gene (1, 2, 5)
Name Description	FLOcculation

Chromosomal Location	ChrV:377614 to 375215 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for FLO8
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA)
Biological Process
Manually curated	biofilm formation (IMP) positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter (IDA, IMP) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: stressResponse (643)
Resources	YEASTRACT | YeTFaSCo

Classical genetics
null	filamentous growth: decreased flocculation: absent invasive growth: absent pseudohyphal growth: absent
overexpression	pseudohyphal growth: increased
Large-scale survey
null	competitive fitness: decreased filamentous growth: decreased haploinsufficient invasive growth: absent resistance to streptomycin: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
overexpression	silencing: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	62 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 3
Genetic Interactions	Dosage Rescue: 20 Negative Genetic: 8 Phenotypic Enhancement: 3 Phenotypic Suppression: 18 Positive Genetic: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:377614 to 375215 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2400 377614..375215 2011-02-03 1999-07-17
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000911