FLO8/YER109C Summary

FLO8 BASIC INFORMATION

Standard Name	FLO8 1, 2
Systematic Name	YER109C
Alias	PHD5 3 , YER108C
Feature Type	ORF, Verified
Description	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene (1, 2, 4)
Name Description	FLOcculation

GO Annotations	All FLO8 GO evidence and references
	View Computational GO annotations for FLO8
Molecular Function
Manually curated	specific RNA polymerase II transcription factor activity (IDA, IMP)
Biological Process
Manually curated	biofilm formation (IMP) flocculation via cell wall protein-carbohydrate interaction (IMP) invasive growth in response to glucose limitation (IMP) positive regulation of gene-specific transcription from RNA polymerase II promoter (IDA, IMP) pseudohyphal growth (IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory Role
Regulatory modules	predicted: stressResponse ( 643 )

Mutant Phenotype	All FLO8 Phenotype details and references
Classical genetics
null	flocculation: absent invasive growth: absent pseudohyphal growth: absent
overexpression	pseudohyphal growth: increased
Large-scale survey
null	filamentous growth: decreased invasive growth: absent viable
overexpression	silencing: abnormal

Interactions	FLO8 All interactions details and references
	32 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 3
Genetic Interactions	Dosage Rescue: 20 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Synthetic Rescue: 3

Sequence Information

ChrV:377610 to 375211 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1999-07-17 | Sequence: 1999-07-17

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2400	377610..375211	1999-07-17	1999-07-17

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000911

FLO8 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FLO8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FLO8]

1)	Kobayashi O, et al. (1996) Molecular cloning and analysis of the dominant flocculation gene FLO8 from Saccharomyces cerevisiae. Mol Gen Genet 251(6):707-15
2)	Liu H, et al. (1996) Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics 144(3):967-78
3)	Gimeno CJ and Fink GR (1994) Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14(3):2100-12
4)	Rupp S, et al. (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69

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