NUP157/YER105C Summary Help

NUP157 BASIC INFORMATION

Standard Name NUP157
Systematic Name YER105C
Feature Type ORF, Verified
Description Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly (1, 2, 3 and see Summary Paragraph)
Name Description NUclear Pore
GO Annotations All NUP157 GO evidence and references
    View Computational GO annotations for NUP157
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All NUP157 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
overexpression
Interactions NUP157 All interactions details and references
44 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 9
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 6
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 4
  • Synthetic Rescue: 1
Sequence Information
ChrV:372009 to 367834 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4176 372009..367834 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000907

NUP157 RESOURCES

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SGD ORF map
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Expression Summary histogram

ADDITIONAL INFORMATION for NUP157

SUMMARY PARAGRAPH for NUP157

NUP157 encodes a nuclear pore protein (2, 4). Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complex (NPC), a large macromolecular complex that spans the nuclear envelope (reviewed in 4, 5, 6, 7). The structure of the vertebrate NPC has been studied extensively; recent reviews include 8, 9, 10, and 11. The yeast NPC shares several features with the vertebrate NPC, despite being smaller and less elaborate (12, 13). Many yeast nuclear pore proteins, or nucleoporins, have been identified by a variety of genetic approaches (reviewed in 4, 5, 14, 15, 16). Nup157p is one of the most abundant yeast nucleoporins (2). Nup157p interacts physically with other abundant yeast nucleoporins, Nic96p, Pom152p, Nup170p, and Nup188p (4). These abundant nucleoporins may form the structural core of the NPC (4). NUP157 is not essential, but nup157 mutations are synthetically lethal with mutations in several other nucleoporin genes (2, 17, 4).

Last updated: 1999-08-11

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NUP157]

1) Rout MP, et al.  (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
2) Aitchison JD, et al.  (1995) Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p. J Cell Biol 131(5):1133-48
3) Makio T, et al.  (2009) The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J Cell Biol 185(3):459-73
4) Fabre E and Hurt E  (1997) Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Annu Rev Genet 31:277-313
5) Wente SR, et al.  (1997) "The nucleus and nucleocytoplasmic transport in Saccharomyces cerevisiae." Pp. 471-546 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by Pringle JR, Broach JR and Jones EW. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
6) Pemberton LF, et al.  (1998) Transport routes through the nuclear pore complex. Curr Opin Cell Biol 10(3):392-9
7) Izaurralde E and Adam S  (1998) Transport of macromolecules between the nucleus and the cytoplasm. RNA 4(4):351-64
8) Hinshaw JE  (1994) Architecture of the nuclear pore complex and its involvement in nucleocytoplasmic transport. Biochem Pharmacol 47(1):15-20
9) Pante N and Aebi U  (1996) Molecular dissection of the nuclear pore complex. Crit Rev Biochem Mol Biol 31(2):153-99
10) Davis LI  (1995) The nuclear pore complex. Annu Rev Biochem 64:865-96
11) Pante N and Aebi U  (1994) Toward the molecular details of the nuclear pore complex. J Struct Biol 113(3):179-89
12) Rout MP and Blobel G  (1993) Isolation of the yeast nuclear pore complex. J Cell Biol 123(4):771-83
13) Yang Q, et al.  (1998) Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications. Mol Cell 1(2):223-34
14) Doye V and Hurt E  (1997) From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol 9(3):401-11
15) Doye V and Hurt EC  (1995) Genetic approaches to nuclear pore structure and function. Trends Genet 11(6):235-41
16) Newmeyer DD  (1993) The nuclear pore complex and nucleocytoplasmic transport. Curr Opin Cell Biol 5(3):395-407
17) Nehrbass U, et al.  (1996) The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex. J Cell Biol 133(6):1153-62