Standard Name	UBC6
Systematic Name	YER100W
Alias	DOA2 1 , 2
Feature Type	ORF, Verified
Description	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway (3, 4, 5, 6)
Name Description	UBiquitin-Conjugating 3

Chromosomal Location	ChrV:359562 to 360314 | ORF Map | GBrowse

	View Computational GO annotations for UBC6
Molecular Function
Manually curated	ubiquitin-protein ligase activity (IDA, IMP)
Biological Process
Manually curated	ER-associated protein catabolic process (IGI, IMP) protein monoubiquitination (TAS) protein polyubiquitination (TAS)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA)

Classical genetics
null	Ura3p-CL1 accumulation: increased CPY* accumulation: increased toxin resistance: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	106 total interaction(s) for 85 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Biochemical Activity: 1 PCA: 2 Protein-peptide: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 54 Phenotypic Enhancement: 7 Phenotypic Suppression: 3 Positive Genetic: 11 Synthetic Growth Defect: 3 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:359562 to 360314 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..753 359562..360314 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000902