PUP3/YER094C Summary

PUP3 BASIC INFORMATION

Standard Name	PUP3
Systematic Name	YER094C
Alias	SCS32
Feature Type	ORF, Verified
Description	Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 (1, 2, 3)
Name Description	PUtative Proteasome subunit

GO Annotations	All PUP3 GO evidence and references
	View Computational GO annotations for PUP3
Molecular Function
Manually curated	endopeptidase activity (TAS)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	proteasome core complex, beta-subunit complex (IPI, TAS)

Mutant Phenotype	All PUP3 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	PUP3 All interactions details and references
	57 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 41 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-crystal Structure: 4 Co-purification: 1 Two-hybrid: 4
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Rescue: 3

Sequence Information

ChrV:349342 to 348725 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..618	349342..348725	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000896

PUP3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PUP3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PUP3]

1)	Groll M, et al. (1997) Structure of 20S proteasome from yeast at 2.4 A resolution. Nature 386(6624):463-71
2)	Jager S, et al. (1999) Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function. J Mol Biol 291(4):997-1013
3)	Nussbaum AK, et al. (1998) Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Proc Natl Acad Sci U S A 95(21):12504-9

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