TRP2/YER090W Summary Help

Standard Name TRP2 1
Systematic Name YER090W
Feature Type ORF, Verified
Description Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p (1, 2, 3, 4)
Name Description TRyPtophan requiring
Chromosomal Location
ChrV:337949 to 339472 | ORF Map | GBrowse
Gbrowse
Genetic position: 76 cM
Gene Ontology Annotations All TRP2 GO evidence and references
  View Computational GO annotations for TRP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 136 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
Resources
109 total interaction(s) for 76 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • PCA: 4
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 61
  • Positive Genetic: 8
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 507
Molecular Weight (Da) 56,767
Isoelectric Point (pI) 5.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:337949 to 339472 | ORF Map | GBrowse
This feature contains embedded feature(s): YER090C-A
SGD ORF map
Genetic position: 76 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1524 337949..339472 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000892
References cited on this page View Complete Literature Guide for TRP2
1) Zalkin H, et al.  (1984) Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase. J Biol Chem 259(6):3985-92
2) Prantl F, et al.  (1985) Purification and characterization of the indole-3-glycerolphosphate synthase/anthranilate synthase complex of Saccharomyces cerevisiae. Eur J Biochem 146(1):95-100
3) Graf R, et al.  (1993) Analysis of feedback-resistant anthranilate synthases from Saccharomyces cerevisiae. J Bacteriol 175(4):1061-8
4) Fantes PA, et al.  (1976) Free tryptophan pool and tryptophan biosynthetic enzymes in Saccharomyces cerevisiae. Arch Microbiol 107(2):207-14