ILV1/YER086W Summary Help

Standard Name ILV1 1
Systematic Name YER086W
Alias ISO1
Feature Type ORF, Verified
Description Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation (2, 3, 4)
Name Description IsoLeucine-plus-Valine requiring
Chromosomal Location
ChrV:328477 to 330207 | ORF Map | GBrowse
Gbrowse
Genetic position: 64 cM
Gene Ontology Annotations All ILV1 GO evidence and references
  View Computational GO annotations for ILV1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
Resources
219 total interaction(s) for 204 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 1
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 101
  • Phenotypic Suppression: 3
  • Positive Genetic: 62
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 576
Molecular Weight (Da) 63,831
Isoelectric Point (pI) 8.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:328477 to 330207 | ORF Map | GBrowse
SGD ORF map
Genetic position: 64 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1731 328477..330207 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000888
References cited on this page View Complete Literature Guide for ILV1
1) Thuriaux P, et al.  (1971) Genetic fine structure and function of mutants at the ilv1-gene locus of Saccharomyces cervisiae. Mol Gen Genet 112(1):60-72
2) Holmberg S and Petersen JG  (1988) Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae. Curr Genet 13(3):207-17
3) Moreira JM, et al.  (2002) Neither Reb1p nor poly(dA*T) elements are responsible for the highly specific chromatin organization at the ILV1 promoter. J Biol Chem 277(5):3202-9
4) Kakar SN and WAGNER RP  (1964) GENETIC AND BIOCHEMICAL ANALYSIS OF ISOLEUCINE-VALINE MUTANTS OF YEAST. Genetics 49():213-22