Standard Name	ILV1 1
Systematic Name	YER086W
Alias	ISO1
Feature Type	ORF, Verified
Description	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation (2, 3, 4)
Name Description	IsoLeucine-plus-Valine requiring

Chromosomal Location	ChrV:328477 to 330207 | ORF Map | GBrowse
	Genetic position: 64 cM

	View Computational GO annotations for ILV1
Molecular Function
Manually curated	L-threonine ammonia-lyase activity (IMP)
Biological Process
Manually curated	isoleucine biosynthetic process (IMP) threonine catabolic process (IGI)
Cellular Component
High-throughput	mitochondrion (IDA)

Pathways	isoleucine biosynthesis superpathway of leucine, isoleucine, and valine biosynthesis

Classical genetics
null	resistance to DFD-VI-15: decreased
unspecified	auxotrophy
Large-scale survey
null	alkaline pH resistance: decreased proton accumulation: increased competitive fitness: decreased heat sensitivity: increased resistance to hydrogen chloride: decreased resistance to CTBT: decreased resistance to mycophenolic acid: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to methyl methanesulfonate: decreased resistance to 2,4-dichlorophenol: decreased resistance to acetic acid: decreased resistance to (S)-lactic acid: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	217 total interaction(s) for 202 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Affinity Capture-RNA: 1 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 101 Phenotypic Suppression: 3 Positive Genetic: 62 Synthetic Growth Defect: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:328477 to 330207 | ORF Map | GBrowse
	Genetic position: 64 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1731 328477..330207 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000888