GET2/YER083C Summary Help

Standard Name GET2 1
Systematic Name YER083C
Alias HUR2 2 , RMD7 3
Feature Type ORF, Verified
Description Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division (1, 3, 4)
Name Description Guided Entry of Tail-anchored proteins 4
Chromosomal Location
ChrV:327031 to 326174 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GET2 GO evidence and references
  View Computational GO annotations for GET2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 101 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
1447 total interaction(s) for 696 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Co-crystal Structure: 4
  • Co-fractionation: 1
  • PCA: 1
  • Reconstituted Complex: 3

Genetic Interactions
  • Negative Genetic: 801
  • Phenotypic Enhancement: 23
  • Phenotypic Suppression: 145
  • Positive Genetic: 133
  • Synthetic Growth Defect: 239
  • Synthetic Lethality: 86
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 285
Molecular Weight (Da) 31,493
Isoelectric Point (pI) 10.29
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:327031 to 326174 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..858 327031..326174 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000885
References cited on this page View Complete Literature Guide for GET2
1) Schuldiner M, et al.  (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19
2) Zewail A, et al.  (2003) Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc Natl Acad Sci U S A 100(6):3345-50
3) Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54
4) Schuldiner M, et al.  (2008) The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell 134(4):634-45