PTP3/YER075C Summary

PTP3 BASIC INFORMATION

Standard Name	PTP3 1
Systematic Name	YER075C
Feature Type	ORF, Verified
Description	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm (2, 3, 4, 5)
Name Description	Protein Tyrosine Phosphatase 1

GO Annotations	All PTP3 GO evidence and references
	View Computational GO annotations for PTP3
Molecular Function
Manually curated	protein tyrosine phosphatase activity (IDA)
Biological Process
Manually curated	inactivation of MAPK activity involved in osmosensory signaling pathway (IMP, IPI) pheromone-dependent signal transduction involved in conjugation with cellular fusion (IMP, IPI) protein amino acid dephosphorylation (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All PTP3 Phenotype details and references
Classical genetics
null	toxin resistance: increased
Large-scale survey
null	polyphosphate accumulation: abnormal viable

Interactions	PTP3 All interactions details and references
	43 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 5 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Phenotypic Enhancement: 11 Phenotypic Suppression: 11 Synthetic Growth Defect: 1 Synthetic Lethality: 3 Synthetic Rescue: 1

Sequence Information

ChrV:311195 to 308409 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2787	311195..308409	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000877

PTP3 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PTP3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PTP3]

1)	Zhan XL, et al. (1997) Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes Dev 11(13):1690-702
2)	Mattison CP, et al. (1999) Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3. Mol Cell Biol 19(11):7651-60
3)	Wurgler-Murphy SM, et al. (1997) Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol Cell Biol 17(3):1289-97
4)	Mattison CP and Ota IM (2000) Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev 14(10):1229-35
5)	Winkler A, et al. (2002) Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress. Eukaryot Cell 1(2):163-73

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.