THO1/YER063W Summary Help

Standard Name THO1 1
Systematic Name YER063W
Feature Type ORF, Verified
Description Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation (1, 2)
Name Description suppressor of the Transcriptional defect of Hpr1 by Overexpression 1
Chromosomal Location
ChrV:281710 to 282366 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All THO1 GO evidence and references
  View Computational GO annotations for THO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Large-scale survey
null
overexpression
Resources
29 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 2
  • PCA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 7
  • Dosage Rescue: 2
  • Negative Genetic: 1
  • Positive Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 218
Molecular Weight (Da) 24,137
Isoelectric Point (pI) 7.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:281710 to 282366 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..657 281710..282366 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000865
References cited on this page View Complete Literature Guide for THO1
1) Piruat JI and Aguilera A  (1998) A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. EMBO J 17(16):4859-72
2) Jimeno S, et al.  (2006) Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants. Mol Cell Biol 26(12):4387-98