HMF1/YER057C Summary Help

Standard Name HMF1 1
Systematic Name YER057C
Alias HIG1
Feature Type ORF, Verified
Description Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication (1, 2, 3)
Name Description Homologous Mmf1p Factor 1
Chromosomal Location
ChrV:271126 to 270737 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HMF1 GO evidence and references
  View Computational GO annotations for HMF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
repressible
Resources
10 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 3
  • PCA: 1

Genetic Interactions
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 129
Molecular Weight (Da) 13,906
Isoelectric Point (pI) 5.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:271126 to 270737 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..390 271126..270737 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000859
References cited on this page View Complete Literature Guide for HMF1
1) Oxelmark E, et al.  (2000) Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome. Mol Cell Biol 20(20):7784-97
2) Deaconescu AM, et al.  (2002) X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). Proteins 48(2):431-6
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61