EDC2/YER035W Summary Help

Standard Name EDC2 1
Systematic Name YER035W
Feature Type ORF, Verified
Description RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Enhancer of mRNA DeCapping 1
Chromosomal Location
ChrV:222639 to 223076 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EDC2 GO evidence and references
  View Computational GO annotations for EDC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 12 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
unspecified
Resources
56 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Co-purification: 1
  • PCA: 4

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 38
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 145
Molecular Weight (Da) 16,071
Isoelectric Point (pI) 10.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:222639 to 223076 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..438 222639..223076 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000837
References cited on this page View Complete Literature Guide for EDC2
1) Dunckley T, et al.  (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157(1):27-37
2) Schwartz D, et al.  (2003) The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme. RNA 9(2):239-51
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Neef DW and Thiele DJ  (2009) Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae. Mol Microbiol 73(6):1032-42
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76