FIR1/YER032W Summary Help

Standard Name FIR1 1
Systematic Name YER032W
Alias PIP1
Feature Type ORF, Verified
Description Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate (2, 3)
Name Description Factor Interacting with REF2
Chromosomal Location
ChrV:215063 to 217693 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FIR1 GO evidence and references
  View Computational GO annotations for FIR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Large-scale survey
null
overexpression
Resources
75 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 25

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 31
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 876
Molecular Weight (Da) 98,811
Isoelectric Point (pI) 7.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:215063 to 217693 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2631 215063..217693 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000834
References cited on this page View Complete Literature Guide for FIR1
1) del Olmo M., et al.,  (1997) Identification of three genes whose products interact with the Saccharomyces cerevisiae poly(A) polymerase in the two-hybrid system. Unpublished
2) Russnak R, et al.  (1996) RNA binding analysis of yeast REF2 and its two-hybrid interaction with a new gene product, FIR1. Gene Expr 6(4):241-58
3) Ostapenko D, et al.  (2012) Identification of anaphase promoting complex substrates in S. cerevisiae. PLoS One 7(9):e45895