Standard Name	RPN3 1
Systematic Name	YER021W
Alias	SUN2 2
Feature Type	ORF, Verified
Description	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control (2, 3, 4, 5)
Name Description	Regulatory Particle Non-ATPase 1

Chromosomal Location	ChrV:196948 to 198519 | ORF Map | GBrowse

	View Computational GO annotations for RPN3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	proteasome regulatory particle, lid subcomplex (IDA)

Large-scale survey
null	haploinsufficient inviable resistance to clioquinol: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased
reduction of function	competitive fitness: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	219 total interaction(s) for 95 unique genes/features.
Physical Interactions	Affinity Capture-MS: 135 Affinity Capture-RNA: 2 Affinity Capture-Western: 15 Co-purification: 6 PCA: 6 Reconstituted Complex: 5 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 29 Phenotypic Enhancement: 1 Positive Genetic: 2 Synthetic Growth Defect: 4 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:196948 to 198519 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1572 196948..198519 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000823