BIM1/YER016W Summary

BIM1 BASIC INFORMATION

Standard Name	BIM1 1
Systematic Name	YER016W
Alias	YEB1
Feature Type	ORF, Verified
Description	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally (2) Also known as: EB1 3
Name Description	BInding to Microtubules 1

GO Annotations	All BIM1 GO evidence and references
	View Computational GO annotations for BIM1
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule depolymerization (IMP) microtubule nucleation (IPI) mitotic cell cycle spindle assembly checkpoint (TAS) mitotic sister chromatid cohesion (IGI, IMP) negative regulation of microtubule depolymerization (IMP) nuclear migration along microtubule (IMP)
Cellular Component
Manually curated	cytoplasmic microtubule (IDA) kinetochore (TAS) spindle (IDA) spindle midzone (IDA) spindle pole (IDA) spindle pole body (IDA)

Mutant Phenotype	All BIM1 Phenotype details and references
Classical genetics
null	colony sectoring: increased
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased resistance to hydroxyurea: decreased resistance to benomyl: decreased sporulation: absent viable
overexpression	inviable

Interactions	BIM1 All interactions details and references
	598 total interaction(s) for 272 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-Western: 11 Biochemical Activity: 1 Co-fractionation: 1 Co-purification: 1 Reconstituted Complex: 3 Two-hybrid: 32
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 95 Phenotypic Suppression: 5 Synthetic Growth Defect: 114 Synthetic Lethality: 320

Sequence Information

ChrV:188276 to 189310 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1035	188276..189310	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000818

BIM1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BIM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BIM1]

1)	Schwartz K, et al. (1997) BIM1 encodes a microtubule-binding protein in yeast. Mol Biol Cell 8(12):2677-91
2)	Miller RK, et al. (2000) Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules. Mol Biol Cell 11(9):2949-59
3)	Su LK, et al. (1995) APC binds to the novel protein EB1. Cancer Res 55(14):2972-7

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