TIR1/YER011W Summary

TIR1/YER011W Summary

Standard Name	TIR1 (see Nomenclature conflict Note)
Systematic Name	YER011W
Alias	SRP1
Feature Type	ORF, Verified
Description	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking (1, 2, 3, 4)
Name Description	TIp1-Related 2

Chromosomal Location	ChrV:175248 to 176012 \| ORF Map \| GBrowse

Gene Ontology Annotations All TIR1 GO evidence and references

	View Computational GO annotations for TIR1
Molecular Function
Manually curated	structural constituent of cell wall (IDA)
Biological Process
Manually curated	response to stress (ISS)
Cellular Component
Manually curated	fungal-type cell wall (IDA)

Mutant phenotypes All TIR1 Phenotype evidence and references

Large-scale survey
null	competitive fitness: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All TIR1 Interaction evidence and references

	11 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 1 Phenotypic Enhancement: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 1
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All TIR1 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrV:175248 to 176012 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..765	175248..176012	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000000813

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
SRP1	Nomenclature conflict	SRP1 has been used to refer to both SRP1/YNL189W, which encodes a protein involved in nucleocytoplasmic transport, and TIR1/YER011W, a serine-rich protein of the cell wall.

References cited on this page View Complete Literature Guide for TIR1

1)	Kitagaki H, et al. (1997) Identification and analysis of a static culture-specific cell wall protein, Tir1p/Srp1p in Saccharomyces cerevisiae. Eur J Biochem 249(1):343-9
2)	Kowalski LR, et al. (1995) Cold-shock induction of a family of TIP1-related proteins associated with the membrane in Saccharomyces cerevisiae. Mol Microbiol 15(2):341-53
3)	Marguet D, et al. (1988) Yeast gene SRP1 (serine-rich protein). Intragenic repeat structure and identification of a family of SRP1-related DNA sequences. J Mol Biol 202(3):455-70
4)	Cohen BD, et al. (2001) Induction and repression of DAN1 and the family of anaerobic mannoprotein genes in Saccharomyces cerevisiae occurs through a complex array of regulatory sites. Nucleic Acids Res 29(3):799-808