SEC3/YER008C Summary Help

SEC3 BASIC INFORMATION

Standard Name SEC3 1, 2
Systematic Name YER008C
Alias PSL1
Feature Type ORF, Verified
Description Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion (3, 4, 5, 6)
Name Description SECretory 7
GO Annotations All SEC3 GO evidence and references
    View Computational GO annotations for SEC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SEC3 Phenotype details and references
Classical genetics
conditional
reduction of function
Large-scale survey
null
repressible
Interactions SEC3 All interactions details and references
129 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • Co-purification: 1
  • Reconstituted Complex: 8
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 22
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 41
  • Synthetic Rescue: 1
Sequence Information
ChrV:171817 to 167807 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 3 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4011 171817..167807 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000810

SEC3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SEC3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC3]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) Finger FP and Novick P  (1998) Spatial regulation of exocytosis: lessons from yeast. J Cell Biol 142(3):609-12
4) Finger FP, et al.  (1998) Sec3p is a spatial landmark for polarized secretion in budding yeast. Cell 92(4):559-71
5) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
6) TerBush DR and Novick P  (1995) Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol 130(2):299-312
7) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62