CIN8/YEL061C Summary

CIN8 BASIC INFORMATION

Standard Name	CIN8
Systematic Name	YEL061C
Alias	KSL2 , SDS15 1
Feature Type	ORF, Verified
Description	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation (2, 3, 4)
Name Description	Chromosome INstability

GO Annotations	All CIN8 GO evidence and references
	View Computational GO annotations for CIN8
Molecular Function
Manually curated	microtubule motor activity (TAS)
Biological Process
Manually curated	microtubule depolymerization (IMP) mitotic anaphase B (IMP) mitotic sister chromatid segregation (IGI) mitotic spindle organization in nucleus (TAS) spindle pole body separation (IGI, IMP)
Cellular Component
Manually curated	astral microtubule (IMP) condensed nuclear chromosome kinetochore (IDA) kinesin complex (TAS) kinetochore microtubule (IDA) spindle microtubule (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All CIN8 Phenotype details and references
Classical genetics
null	cell cycle progression in anaphase: delayed chromosome segregation: abnormal colony sectoring: increased resistance to cincreasin: decreased spindle morphology: abnormal
overexpression	cell cycle passage through the metaphase-anaphase transition: delayed spindle morphology: abnormal
Large-scale survey
null	competitive fitness: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to rapamycin: decreased resistance to wortmannin: normal resistance to benomyl: decreased resistance to St. John's Wort extract: decreased viable

Interactions	CIN8 All interactions details and references
	382 total interaction(s) for 203 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-Western: 2 PCA: 1 Two-hybrid: 8
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Phenotypic Enhancement: 98 Phenotypic Suppression: 6 Synthetic Growth Defect: 46 Synthetic Lethality: 204 Synthetic Rescue: 7

Sequence Information

ChrV:39537 to 36535 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2003-09-22 | Sequence: 2003-09-22

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3003	39537..36535	2003-09-22	2003-09-22

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000787

CIN8 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CIN8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CIN8]

1)	Sussel L, et al. (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88
2)	Hoyt MA, et al. (1992) Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J Cell Biol 118(1):109-20
3)	Saunders WS and Hoyt MA (1992) Kinesin-related proteins required for structural integrity of the mitotic spindle. Cell 70(3):451-8
4)	Roof DM, et al. (1992) Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol 118(1):95-108

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