Standard Name	HAT2
Systematic Name	YEL056W
Feature Type	ORF, Verified
Description	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing (1, 2, 3)
Name Description	Histone AcetylTransferase 2

Chromosomal Location	ChrV:47168 to 48373 | ORF Map | GBrowse

	View Computational GO annotations for HAT2
Molecular Function
Manually curated	contributes_to histone acetyltransferase activity (IDA, IMP, IPI) histone binding (IDA)
Biological Process
Manually curated	chromatin assembly or disassembly (IDA) chromatin silencing at telomere (IGI) histone acetylation (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) histone acetyltransferase complex (IDA, IPI) nucleus (IDA)

Classical genetics
null	Hat1-HA distribution: abnormal replicative lifespan: increased silencing: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to bleomycin: increased resistance to benzo[a]pyrene: increased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	116 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 56 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Co-fractionation: 1 Co-purification: 2 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 28 Phenotypic Enhancement: 1 Positive Genetic: 3 Synthetic Growth Defect: 9 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:47168 to 48373 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1206 47168..48373 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000782