IES6/YEL044W Summary Help

Standard Name IES6 1
Systematic Name YEL044W
Feature Type ORF, Verified
Description Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes (1, 2, 3, 4, 5)
Name Description Ino Eighty Subunit 1
Chromosomal Location
ChrV:69757 to 70257 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IES6 GO evidence and references
  View Computational GO annotations for IES6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 16 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
41 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 4
  • Co-purification: 1
  • Reconstituted Complex: 4

Genetic Interactions
  • Dosage Lethality: 1
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 9
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 166
Molecular Weight (Da) 18,533
Isoelectric Point (pI) 11.05
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:69757 to 70257 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..501 69757..70257 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000770
References cited on this page View Complete Literature Guide for IES6
1) Shen X, et al.  (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
2) Morrison AJ, et al.  (2004) INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell 119(6):767-75
3) Jin J, et al.  (2005) A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J Biol Chem 280(50):41207-12
4) Chambers AL, et al.  (2012) The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes Dev 26(23):2590-603
5) Tosi A, et al.  (2013) Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex. Cell 154(6):1207-19