Standard Name	ANP1 1
Systematic Name	YEL036C
Alias	GEM3 , MNN8
Feature Type	ORF, Verified
Description	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol (1, 2)
Name Description	ANP and osmotic sensitive 1

Chromosomal Location	ChrV:84552 to 83050 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -26 cM

	View Computational GO annotations for ANP1
Molecular Function
Manually curated	contributes_to alpha-1,6-mannosyltransferase activity (IDA) mannosyltransferase activity (ISS)
Biological Process
Manually curated	protein N-linked glycosylation (IDA, IMP)
Cellular Component
Manually curated	alpha-1,6-mannosyltransferase complex (IPI) Golgi cis cisterna (IDA)

Classical genetics
null	triglyceride accumulation: increased sterol ester accumulation: increased resistance to mycophenolic acid: decreased resistance to Calcofluor White: decreased
unspecified	Suc2p modification: decreased resistance to hygromycin B: decreased resistance to sodium orthovanadate: increased
Large-scale survey
null	acid pH resistance: decreased alkaline pH resistance: decreased bud morphology: abnormal cell size: increased glycogen accumulation: increased glutathione excretion: increased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased freeze-thaw resistance: decreased haploinsufficient heat sensitivity: increased lipid particle morphology: abnormal metal resistance: decreased Fus-Mid-GFP distribution: abnormal resistance to CTBT: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to sulfanilamide: decreased resistance to propan-1-ol: decreased resistance to methanol: decreased resistance to L-1,4-dithiothreitol: decreased resistance to hygromycin B: decreased resistance to sirolimus: decreased resistance to doxorubicin: decreased resistance to cadmium dichloride: decreased resistance to trichothecene: increased resistance to ethanol: decreased resistance to caffeine: decreased resistance to glucose: decreased resistance to acetic acid: decreased resistance to sorbate: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	546 total interaction(s) for 509 unique genes/features.
Physical Interactions	Affinity Capture-MS: 27 Affinity Capture-RNA: 1 Affinity Capture-Western: 16 Co-fractionation: 6 Co-purification: 1 PCA: 1
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 1 Negative Genetic: 360 Positive Genetic: 120 Synthetic Growth Defect: 4 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:84552 to 83050 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -26 cM
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1503 84552..83050 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000762