EAF5/YEL018W Summary Help

Standard Name EAF5 1
Systematic Name YEL018W
Feature Type ORF, Verified
Description Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description Esa1p-Associated Factor 1
Chromosomal Location
ChrV:121471 to 122310 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EAF5 GO evidence and references
  View Computational GO annotations for EAF5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
overexpression
Resources
412 total interaction(s) for 234 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 39
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 17
  • Co-crystal Structure: 2
  • Co-purification: 1
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 14
  • Dosage Lethality: 6
  • Negative Genetic: 188
  • Positive Genetic: 23
  • Synthetic Growth Defect: 97
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 21

Resources
Expression Summary
histogram
Resources
Length (a.a.) 279
Molecular Weight (Da) 31,644
Isoelectric Point (pI) 8.9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:121471 to 122310 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..840 121471..122310 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000744
References cited on this page View Complete Literature Guide for EAF5
1) Nourani A, et al.  (2001) Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol 21(22):7629-40
2) Krogan NJ, et al.  (2004) Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A 101(37):13513-8
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30